By determining the optimal timing of pacing in heart failure patients, the pacemaker can maximize the heart’s output of blood to the body. It has been demonstrated that allowing these hearts to beat in a synchronous fashion, similar to a healthy heart, improves patient symptoms and keeps patients out of the hospital. Cardiac Resynchronization Therapy (CRT) is the practice of using bi-ventricular pacing to reduce the dyssynchrony of a weakened heart in an effort to improve its pump function (SV). Maximizing SV and minimizing left ventricular end systolic volume (ESV) are used to tune these pacemakers to their optimal settings with echocardiography during a visit to the hospital or doctor’s office.


Optimizing CRT is usually done with echocardiography, but requires an independent procedure involving both the echo technician and an additional technician to reprogram the pacing mode as each sequence is assessed. Current implementations of CRT have had limited success for two reasons: 1) CRT is not adaptive to acutely changing patient conditions, in particular activities of daily living and exercise, and 2) optimization typically only takes place once (during the initial implant), and thus is not capable of correcting for heart remodeling without regular physician visits.


Admittance Technologies proposes a self-tuning CRT which can intelligently and automatically alter the pacing to provide real-time hemodynamic optimization in vivo for the first time — Adaptive Cardiac Resynchronization Therapy (ACRT).